Zika virus antagonizes interferon response in patients and disrupts RIG-I–MAVS interaction through its CARD-TM domains
Abstract Background The emerging threat to global health associated with the Zika virus (ZIKV) epidemics and its link to severe complications highlights a growing need to better understand the pathogenic mechanisms of ZIKV. Accumulating evidence for a critical role of type I interferon (IFN-I) in pr...
Main Authors: | Yiwen Hu, Xinhuai Dong, Zhenjian He, Yun Wu, Shihao Zhang, Jiajie Lin, Yi Yang, Jiahui Chen, Shu An, Yingxian Yin, Zhiyong Shen, Gucheng Zeng, Han Tian, Junchao Cai, Hongyu Guan, Jueheng Wu, Mengfeng Li, Xun Zhu |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-06-01
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Series: | Cell & Bioscience |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13578-019-0308-9 |
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