Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence

Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence

Abstract Background Sunitinib, a receptor tyrosine kinase (RTK) inhibitor that targets multiple receptors such as vascular endothelial growth factor receptors (VEGFRs), was approved for cancer treatment in 2006. However, it was unsuccessful in treating certain cancers, particularly metastatic breast...

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Bibliographic Details
Main Authors: Denian Wang, Fei Xiao, Zhongxue Feng, Min Li, Lingmiao Kong, Luping Huang, Yong’gang Wei, Hongyu Li, Fei Liu, Haili Zhang, Wei Zhang
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Breast Cancer Research
Subjects:
Sunitinib
Metastatic breast cancer (MBC)
Receptor tyrosine kinase (RTK)
Cell senescence
Metastasis
Online Access:http://link.springer.com/article/10.1186/s13058-020-01346-y

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http://link.springer.com/article/10.1186/s13058-020-01346-y

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