Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells

Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells

We recently identified elevated annexin A6 (AnxA6) protein levels in Niemann–Pick-type C1 (NPC1) mutant cells. In these cells, AnxA6 depletion rescued the cholesterol accumulation associated with NPC1 deficiency. Here, we demonstrate that elevated AnxA6 protein levels in NPC1 mutants or upon pharmac...

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Bibliographic Details
Main Authors: Elsa Meneses-Salas, Ana García-Melero, Patricia Blanco-Muñoz, Jaimy Jose, Marie-Sophie Brenner, Albert Lu, Francesc Tebar, Thomas Grewal, Carles Rentero, Carlos Enrich
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
cholesterol
AnxA6
chaperone-mediated autophagy
endolysosomes
NPC1
Lamp2A.
Online Access:https://www.mdpi.com/2073-4409/9/5/1152

Internet

https://www.mdpi.com/2073-4409/9/5/1152

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