Comprehensive Evaluation of Immune-Checkpoint DNA Cancer Vaccines in a Rat Cholangiocarcinoma Model

Comprehensive Evaluation of Immune-Checkpoint DNA Cancer Vaccines in a Rat Cholangiocarcinoma Model

Cholangiocarcinoma (CCA) is a malignant tumor with aggressive biological behavior. Immune checkpoints such as cytotoxic T-lymphocyte antigen 4 (CTLA4) and antiprogrammed death 1 (PD-1) are critical immune-checkpoint molecules that repress T-cell activation. The DNA vaccine potential against CTLA4 an...

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Bibliographic Details
Main Authors: Yi-Ru Pan, Chiao-En Wu, Ming-Huang Chen, Wen-Kuan Huang, Hsuan-Jen Shih, Keng-Li Lan, Chun-Nan Yeh
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Vaccines
Subjects:
cholangiocarcinoma
PD-1
PD-L1
CTLA4
DNA vaccine
Online Access:https://www.mdpi.com/2076-393X/8/4/703

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https://www.mdpi.com/2076-393X/8/4/703

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