Delayed Degradation and Impaired Dendritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice

Delayed Degradation and Impaired Dendritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice

Arc is a unique immediate early gene (IEG) whose expression is induced as synapses are modified during learning. Newly-synthesized Arc mRNA is rapidly transported throughout dendrites and localizes near recently activated synapses. Arc mRNA levels are regulated by rapid degradation, which is acceler...

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Bibliographic Details
Main Authors: Oswald Steward, Kelly Matsudaira Yee, Shannon Farris, Patricia S. Pirbhoy, Paul Worley, Kohji Okamura, Hiroyuki Okuno, Haruhiko Bito
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
LTP
synaptic plasticity
protein synthesis
dendrite
dendritic mRNA
dendritic spines
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00435/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00435/full

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