The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells

The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells

Abstract Background The HIV-1 accessory proteins Nef and Vpu alter cell surface levels of multiple host proteins to modify the immune response and increase viral persistence. Nef and Vpu can downregulate cell surface levels of the co-stimulatory molecule CD28, however the mechanism of this function...

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Bibliographic Details
Main Authors: Emily N. Pawlak, Brennan S. Dirk, Rajesh Abraham Jacob, Aaron L. Johnson, Jimmy D. Dikeakos
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Retrovirology
Subjects:
HIV-1 Nef
HIV-1 Vpu
CD28 downregulation
T cell activation
Online Access:http://link.springer.com/article/10.1186/s12977-018-0388-3

Internet

http://link.springer.com/article/10.1186/s12977-018-0388-3

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