Production of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS+ circulating memory T follicular-helper cells which is impaired by HIV infection.

Production of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS+ circulating memory T follicular-helper cells which is impaired by HIV infection.

Dysfunction of T follicular-helper (TFH) cells is a possible cause of impaired germinal centre (GC) and IgG antibody responses in individuals with human immunodeficiency virus-1 (HIV-1) infection and might contribute to decreased magnitude and isotype diversification of IgG antibodies to pneumococca...

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Bibliographic Details
Main Authors: Laila N Abudulai, Sonia Fernandez, Karli Corscadden, Sally A Burrows, Michael Hunter, M Christian Tjiam, Lea-Ann S Kirkham, Jeffrey J Post, Martyn A French
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5413043?pdf=render

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http://europepmc.org/articles/PMC5413043?pdf=render

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