A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress

A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress

Abstract Background Mantle cell lymphoma (MCL) is a B-cell hemopathy characterized by the t(11;14) translocation and the aberrant overexpression of cyclin D1. This results in an unrestrained cell proliferation. Other genetic alterations are common in MCL cells such as SOX11 expression, mutations of...

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Bibliographic Details
Main Authors: Khaoula Ben Younes, Simon Body, Élodie Costé, Pierre-Julien Viailly, Hadjer Miloudi, Clémence Coudre, Fabrice Jardin, Fatma Ben Aissa-Fennira, Brigitte Sola
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Cancer
Subjects:
B-cell lymphoma
Apoptosis
Cell cycle
Senescence
Resistance/sensitivity
Double-strand break
Online Access:http://link.springer.com/article/10.1186/s12885-017-3530-z

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http://link.springer.com/article/10.1186/s12885-017-3530-z

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