Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives

Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives

The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized pri...

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Bibliographic Details
Main Authors: Luciana Méndez, Andrés A. Poeylaut-Palena, Ernesto G. Mata
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Molecules
Subjects:
diversity oriented synthesis
solid-phase organic synthesis
β-lactam derivatives
olefin metathesis
cholesterol absorption inhibitors
Online Access:http://www.mdpi.com/1420-3049/23/5/1193

Internet

http://www.mdpi.com/1420-3049/23/5/1193

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