Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model

Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model

Specific neuroprotective strategies to minimize cerebral damage caused by severe hypoxia or hypovolemia are lacking. Based on previous studies showing that relaxin-2/serelaxin increases cortical cerebral blood flow, we postulated that serelaxin might provide a neuroprotective effect. Therefore, we t...

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Bibliographic Details
Main Authors: René Schiffner, Sabine J. Bischoff, Thomas Lehmann, Andrey Irintchev, Marius Nistor, Cornelius Lemke, Martin Schmidt
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
neuroprotection
cerebral blood flow
relaxin-2
relaxin receptors
sheep model
hypoxia
shock
Online Access:https://www.mdpi.com/1422-0067/21/5/1632

Internet

https://www.mdpi.com/1422-0067/21/5/1632

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