Eradication of unresectable liver metastasis through induction of tumour specific energy depletion

Treatment of liver metastasis in cancer patients is associated with severe side effects. Here, the authors develop nucleus and mitochondria targeted nanoparticles, conjugated via a cathepsin B sensitive peptide to selectively target liver metastatic cells.

Bibliographic Details
Main Authors: Da Huo, Jianfeng Zhu, Guojun Chen, Qian Chen, Chao Zhang, Xingyu Luo, Wei Jiang, Xiqun Jiang, Zhen Gu, Yong Hu
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11082-3