FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome

FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome

Wiskott–Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the WAS gene, which together with its homolog, N-WASP, regulates actin cytoskeleton remodeling and cell motility. WAS patients suffer from microthrombocytopenia, characterized by a diminished num...

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Bibliographic Details
Main Authors: Chunlin Wang, Klarke M. Sample, Babu Gajendran, Philipp Kapranov, Wuling Liu, Anling Hu, Eldad Zacksenhaus, Yanmei Li, Xiaojiang Hao, Yaacov Ben-David
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
Wiskott–Aldrich Syndrome
megakaryopoiesis
microthrombocytopenia
FLI1
immunodeficiency
WASP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.607836/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.607836/full

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