Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike

Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike

There are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. The beta-CoV Spike protein is a promising target considering the critical role in viral infection and pathogenesis and its surface exposed features. We performed a structure-based strategy targeting highly conserved dru...

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Bibliographic Details
Main Authors: João Trigueiro-Louro, Vanessa Correia, Inês Figueiredo-Nunes, Marta Gíria, Helena Rebelo-de-Andrade
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Betacoronavirus
Coronavirus disease
Druggability prediction
Novel antiviral targets
SARS-CoV-2
Sequence conservation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020303494

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http://www.sciencedirect.com/science/article/pii/S2001037020303494

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