FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2

Abstract Background The tumor suppressor FBW7 is the substrate recognition component of the SCF E3-ubiquitin ligase complex that mediates proteolytic degradation of various oncogenic proteins. However, the role of FBW7 in ovarian cancer progression remains inadequately understood. Methods IP-MASS, c...

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Bibliographic Details
Main Authors: Fei Xu, Jiajia Li, Mengdong Ni, Jingyi Cheng, Haiyun Zhao, Shanshan Wang, Xiang Zhou, Xiaohua Wu
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Cancer
Subjects:
FBW7
YTHDF2
BMF
N6-methyladenosine
Ubiquitination
Online Access:https://doi.org/10.1186/s12943-021-01340-8

Internet

https://doi.org/10.1186/s12943-021-01340-8

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