A Novel Integrated Way for Deciphering the Glycan Code for the FimH Lectin

A Novel Integrated Way for Deciphering the Glycan Code for the FimH Lectin

The fimbrial lectin FimH from uro- and enteropathogenic <i>Escherichia coli</i> binds with nanomolar affinity to oligomannose glycans exposing Man&#945;1,3Man dimannosides at their non-reducing end, but only with micromolar affinities to Man&#945;1,2Man dimannosides. These two di...

Full description

Bibliographic Details
Main Authors: Tetiana Dumych, Clarisse Bridot, Sébastien G. Gouin, Marc F. Lensink, Solomiya Paryzhak, Sabine Szunerits, Ralf Blossey, Rostyslav Bilyy, Julie Bouckaert, Eva-Maria Krammer
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
Manα1,3Man
Manα1,2Man
FimH
binding mode
Enzyme-Linked LectinoSorbent assay
microcalorimetry
molecular dynamics
thermodynamics
entropy
high-mannose <i>N</i>-glycan
Online Access:https://www.mdpi.com/1420-3049/23/11/2794

Internet

https://www.mdpi.com/1420-3049/23/11/2794

Similar Items