Noradrenaline Increases mEPSC Frequency in Pyramidal Cells in Layer II of Rat Barrel Cortex via Calcium Release From Presynaptic Stores

Noradrenaline Increases mEPSC Frequency in Pyramidal Cells in Layer II of Rat Barrel Cortex via Calcium Release From Presynaptic Stores

Somatosensory cortex is innervated by afferents originating from the locus coeruleus which typically release noradrenaline. We tested if activation of presynaptic α1-adrenoceptors (AR) coupled to a Gq-mediated signaling cascade resulted in calcium (Ca2+) release from stores and thereby increased spo...

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Bibliographic Details
Main Authors: Julian M. C. Choy, Fransiscus A. Agahari, Li Li, Christian Stricker
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
α1-adrenoceptor
presynaptic calcium stores
mEPSC
noradrenaline
neuromodulation
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00213/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00213/full

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