Optimal parameter identification of synthetic gene networks using harmony search algorithm.

Computational modeling of engineered gene circuits is an important while challenged task in systems biology. In order to describe and predict the response behaviors of genetic circuits using reliable model parameters, this paper applies an optimal experimental design(OED) method to obtain input sign...

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Bibliographic Details
Main Authors: Wei Zhang, Wenchao Li, Jianming Zhang, Ning Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213977