Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq

Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq

Abstract B cell response plays a critical role against SARS-CoV-2 infection. However, little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection. Here, we performed single-cell RNA sequencing and VDJ sequencing using the memo...

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Bibliographic Details
Main Authors: Bing He, Shuning Liu, Yuanyuan Wang, Mengxin Xu, Wei Cai, Jia Liu, Wendi Bai, Shupei Ye, Yong Ma, Hengrui Hu, Huicui Meng, Tao Sun, Yanling Li, Huanle Luo, Mang Shi, Xiangjun Du, Wenjing Zhao, Shoudeng Chen, Jingyi Yang, Haipeng Zhu, Yusheng Jie, Yuedong Yang, Deyin Guo, Qiao Wang, Yuwen Liu, Huimin Yan, Manli Wang, Yao-Qing Chen
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00610-7

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https://doi.org/10.1038/s41392-021-00610-7

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