Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model

Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model

Type I collagen is the major structural component of lung stroma. Because of its long half-life, type I collagen undergoes post-translational modifications such as glycation during aging process. These modifications have been shown to impact the structural organization of type I collagen fibers. In...

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Bibliographic Details
Main Authors: Thomas Sarazin, Guillaume Collin, Emilie Buache, Laurence Van Gulick, Céline Charpentier, Christine Terryn, Hamid Morjani, Charles Saby
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
Type I collagen
aging
EGFR
Erlotinib
resistance
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01593/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01593/full

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