Deletion of the innate immune NLRP3 receptor abolishes cardiac ischemic preconditioning and is associated with decreased Il-6/STAT3 signaling.

Deletion of the innate immune NLRP3 receptor abolishes cardiac ischemic preconditioning and is associated with decreased Il-6/STAT3 signaling.

Recent studies indicate that the innate immune system is not only triggered by exogenous pathogens and pollutants, but also by endogenous danger signals released during ischemia and necrosis. As triggers for the innate immune NLRP3 inflammasome protein complex appear to overlap with those for cardia...

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Bibliographic Details
Main Authors: Coert J Zuurbier, Willeke M C Jong, Otto Eerbeek, Anneke Koeman, Wilco P Pulskens, Loes M Butter, Jaklien C Leemans, Markus W Hollmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3407219?pdf=render

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http://europepmc.org/articles/PMC3407219?pdf=render

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