Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5

Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5

<p>Abstract</p> <p>Background</p> <p>Clinical gene therapy trials for cardiovascular diseases have demonstrated the crucial role of efficient gene delivery and transfection technologies in achieving clinically relevant results. We hypothesized that the use of tropism-mo...

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Bibliographic Details
Main Authors: Toivonen Raine, Koskenvuo Juha, Merentie Mari, Söderström Mirva, Ylä-Herttuala Seppo, Savontaus Mikko
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Virology Journal
Subjects:
Adenovirus
Intracardiac injection
CAR
CD46
Targeting
Online Access:http://www.virologyj.com/content/9/1/296

Internet

http://www.virologyj.com/content/9/1/296

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