The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but subsequent studies did not observe these lesions. The c...

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Bibliographic Details
Main Authors: Jacob T Polaski, Dylan B Udy, Luisa F Escobar-Hoyos, Gokce Askan, Steven D Leach, Andrea Ventura, Ram Kannan, Robert K Bradley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
pancreatic cancer
cancer genomics
cancer genetics
Online Access:https://elifesciences.org/articles/62209

Internet

https://elifesciences.org/articles/62209

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