Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance.

Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance.

We have previously demonstrated that Sinupret, an established treatment prescribed widely in Europe for respiratory ailments including rhinosinusitis, promotes transepithelial chloride (Cl-) secretion in vitro and in vivo. The present study was designed to evaluate other indicators of mucociliary cl...

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Bibliographic Details
Main Authors: Shaoyan Zhang, Daniel Skinner, Stephen Bradley Hicks, Mark O Bevensee, Eric J Sorscher, Ahmed Lazrak, Sadis Matalon, Carmel M McNicholas, Bradford A Woodworth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4130514?pdf=render

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http://europepmc.org/articles/PMC4130514?pdf=render

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