VAPB ER-Aggregates, A Possible New Biomarker in ALS Pathology

VAPB ER-Aggregates, A Possible New Biomarker in ALS Pathology

A point mutation (P56S) in the gene-encoding vesicle-associated membrane-protein-associated protein B (VAPB) leads to an autosomal-dominant form of amyotrophic lateral sclerosis (ALS), classified as ALS-8. The mutant VAPB is characterized by ER-associated aggregates that lead to a complete reorganiz...

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Bibliographic Details
Main Authors: Maria Piera L Cadoni, Maria Luigia Biggio, Giannina Arru, Giannina Secchi, Nicola Orrù, Maria Grazia Clemente, GianPietro Sechi, Alfred Yamoah, Priyanka Tripathi, Sandro Orrù, Roberto Manetti, Grazia Galleri
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
als
biomarker
vapb er-aggregates
endoplasmic reticulum
flow cytometry
pbmc
immunofluorescence
Online Access:https://www.mdpi.com/2073-4409/9/1/164

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https://www.mdpi.com/2073-4409/9/1/164

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