Insights into Structure-Activity Relationships of Somatostatin Analogs Containing Mesitylalanine

Insights into Structure-Activity Relationships of Somatostatin Analogs Containing Mesitylalanine

The non-natural amino acid mesitylalanine (2,4,6-trimethyl-L-phenylalanine; Msa) has an electron-richer and a more conformationally restricted side-chain than that of its natural phenylalanine counterpart. Taking these properties into account, we have synthesized ten somatostatin analogs containing...

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Bibliographic Details
Main Authors: Pablo Martín-Gago, Eric Aragón, Marc Gomez-Caminals, Jimena Fernández-Carneado, Rosario Ramón, Pau Martin-Malpartida, Xavier Verdaguer, Pilar López-Ruiz, Begoña Colás, María Alicia Cortes, Berta Ponsati, Maria J. Macias, Antoni Riera
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Molecules
Subjects:
somatostatin
drug design
peptidic hormones
non-covalent interactions
NMR
structure-activity relationships
conformational analysis
Online Access:http://www.mdpi.com/1420-3049/18/12/14564

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http://www.mdpi.com/1420-3049/18/12/14564

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