CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity

CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity

CD96 is a transmembrane glycoprotein Ig superfamily receptor, expressed on various T cell subsets and NK cells, that interacts with nectin and nectin-like proteins, including CD155/polio virus receptor (PVR). Here, we have compared three rat anti-mouse CD96 mAbs, including two that block CD96-CD155...

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Bibliographic Details
Main Authors: Amelia Roman Aguilera, Viviana P. Lutzky, Deepak Mittal, Xian-Yang Li, Kimberley Stannard, Kazuyoshi Takeda, Günter Bernhardt, Michele W. L. Teng, William C. Dougall, Mark J. Smyth
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
nk cells
metastasis
immunotherapy
cd96
cd155
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1424677

Internet

http://dx.doi.org/10.1080/2162402X.2018.1424677

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