Introduction of the MASH1 gene into mouse embryonic stem cells leads to differentiation of motoneuron precursors lacking Nogo receptor expression that can be applicable for transplantation to spinal cord injury

Introduction of the MASH1 gene into mouse embryonic stem cells leads to differentiation of motoneuron precursors lacking Nogo receptor expression that can be applicable for transplantation to spinal cord injury

ES cells transfected with the MASH1 gene yielded purified spinal motoneuron precursors expressing HB9 and Islet1. The cells lacked the expression of Nogo receptor that was of great advantage for axon growth after transplantation to an injured spinal cord. After transplantation, mice with the complet...

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Bibliographic Details
Main Authors: Mari Hamada, Hideshi Yoshikawa, Yuji Ueda, Manae S. Kurokawa, Kenji Watanabe, Manabu Sakakibara, Mamoru Tadokoro, Katsuya Akashi, Haruhito Aoki, Noboru Suzuki
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neurobiology of Disease
Subjects:
ES cells
Differentiation
Spinal cord
Motoneuron
Nogo receptor
Spinal cord injury
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105003475

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http://www.sciencedirect.com/science/article/pii/S0969996105003475

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