Discovery and Preclinical Development of Orally Active Small Molecules that Exhibit Highly Selective Follicle Stimulating Hormone Receptor Agonism

Discovery and Preclinical Development of Orally Active Small Molecules that Exhibit Highly Selective Follicle Stimulating Hormone Receptor Agonism

An orally active follicle stimulating hormone receptor allosteric agonist would provide a preferred treatment for over 16 million infertile women of reproductive age in low complexity methods (ovulation induction-intrauterine insemination) or in high complexity methods (controlled ovarian stimulatio...

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Bibliographic Details
Main Authors: Selva Nataraja, Henry Yu, Joie Guner, Stephen Palmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
follicle stimulating hormone
oral FSHR allosteric agonist
G-protein coupled receptor
infertility treatment
follicular maturation
oocyte viability
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.602593/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.602593/full

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