Increased Excitability and Reduced Excitatory Synaptic Input Into Fast-Spiking CA2 Interneurons After Enzymatic Attenuation of Extracellular Matrix

Increased Excitability and Reduced Excitatory Synaptic Input Into Fast-Spiking CA2 Interneurons After Enzymatic Attenuation of Extracellular Matrix

The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus. However, ECM molecules are strongly expresse...

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Bibliographic Details
Main Authors: Hussam Hayani, Inseon Song, Alexander Dityatev
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hippocampus
perineuronal net
WFA
fast-spiking interneuron
excitability
excitatory input
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00149/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00149/full

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