8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABAA Receptor

8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABAA Receptor

In order to develop improved anxiolytic drugs, 8-substituted analogs of triazolam were synthesized in an effort to discover compounds with selectivity for α2/α3 subunit-containing GABAA subtypes. Two compounds in this series, XLi-JY-DMH (6-(2-chlorophenyl)-8-ethynyl-1-methyl-4H-benzo [f][1,2,4]triaz...

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Bibliographic Details
Main Authors: Lalit K. Golani, Donna M. Platt, Daniela Rüedi-Bettschen, Chitra Edwanker, Shenming Huang, Michael M. Poe, Roman Furtmüller, Werner Sieghart, James M. Cook, James K. Rowlett
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
benzodiazepine
anxiolytic
sedation
squirrel monkey
rhesus monkey
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.625233/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.625233/full

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