Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence

Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence

Abstract Background Spindle assembly checkpoint components BubR1 and Sgo1 play a key role in the maintenance of chromosomal instability during cell division. These proteins function to block the anaphase entry until all condensed chromosomes have been attached by the microtubules emanating from both...

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Bibliographic Details
Main Authors: Sung-Hyun Park, Steve Xie, Chinthalapally V. Rao, Wei Dai
Format: Article
Language:English
Published: BMC 2016-02-01
Series:Journal of Hematology & Oncology
Subjects:
BubR1
SGO1
Knockout mice
MEFs
Senescence
Online Access:http://link.springer.com/article/10.1186/s13045-016-0238-5

Internet

http://link.springer.com/article/10.1186/s13045-016-0238-5

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