The English (H6R) Mutation of the Alzheimer’s Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation

The English (H6R) Mutation of the Alzheimer’s Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation

The coordination of zinc ions by histidine residues of amyloid-beta peptide (Aβ) plays a critical role in the zinc-induced Aβ aggregation implicated in Alzheimer’s disease (AD) pathogenesis. The histidine to arginine substitution at position 6 of the Aβ sequence (H6R, English mutation) leads to an e...

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Bibliographic Details
Main Authors: Sergey P. Radko, Svetlana A. Khmeleva, Dmitry N. Kaluzhny, Olga I. Kechko, Yana Y. Kiseleva, Sergey A. Kozin, Vladimir A. Mitkevich, Alexander A. Makarov
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomolecules
Subjects:
amyloid-β
English mutation
zinc
aggregation
Online Access:https://www.mdpi.com/2218-273X/10/6/961

Internet

https://www.mdpi.com/2218-273X/10/6/961

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