G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases

G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases

G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory functions in other cell signaling routes. GRK2 levels and activity have been reported to be enhanced in patients or in preclini...

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Bibliographic Details
Main Authors: Cristina Murga, Alba C. Arcones, Marta Cruces-Sande, Ana M. Briones, Mercedes Salaices, Federico Mayor Jr.
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
GRK2
GPCR
cardiovascular
obesity
NAFLD
insulin resistance
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00112/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00112/full

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