Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin αIIbβ3 inside-out but not outside-in signals

Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin αIIbβ3 inside-out but not outside-in signals

Abstract Background Columbianadin (CBN) is one of the main coumarin constituents isolated from Angelica pubescens. The pharmacological value of CBN is well demonstrated, especially in the prevention of several cancers and analgesic activity. A striking therapeutic target for arterial thrombosis is i...

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Bibliographic Details
Main Authors: Shaw-Min Hou, Chih-Wei Hsia, Cheng-Lin Tsai, Chih-Hsuan Hsia, Thanasekaran Jayakumar, Marappan Velusamy, Joen-Rong Sheu
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Biomedical Science
Subjects:
CBN
Coumarin derivative
Platelet aggregation
Arterial thrombosis
Integrin αIIbβ3
Online Access:http://link.springer.com/article/10.1186/s12929-020-0619-5

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http://link.springer.com/article/10.1186/s12929-020-0619-5

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