DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity

DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity

Summary: DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects higher-order levels of genome architecture is...

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Bibliographic Details
Main Authors: Qian Du, Grady C. Smith, Phuc Loi Luu, James M. Ferguson, Nicola J. Armstrong, C. Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena Zotenko, Cathryn M. Gould, Michael Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik Kaczorowski, Chia-Ling Chan, Kirston Barton, Ira W. Deveson, Martin A. Smith, Joseph E. Powell, Ksenia Skvortsova, Clare Stirzaker, Joanna Achinger-Kawecka, Susan J. Clark
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
replication timing
DNA methylation
epigenome
chromatin
single-cell sequencing
allele-specific replication
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011712

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http://www.sciencedirect.com/science/article/pii/S2211124721011712

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