The germline variants in DNA repair genes in pediatric medulloblastoma: a challenge for current therapeutic strategies

The germline variants in DNA repair genes in pediatric medulloblastoma: a challenge for current therapeutic strategies

Abstract Background The defects in DNA repair genes are potentially linked to development and response to therapy in medulloblastoma. Therefore the purpose of this study was to establish the spectrum and frequency of germline variants in selected DNA repair genes and their impact on response to chem...

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Bibliographic Details
Main Authors: Joanna Trubicka, Tomasz Żemojtel, Jochen Hecht, Katarzyna Falana, Dorota Piekutowska- Abramczuk, Rafał Płoski, Marta Perek-Polnik, Monika Drogosiewicz, Wiesława Grajkowska, Elżbieta Ciara, Elżbieta Moszczyńska, Bożenna Dembowska-Bagińska, Danuta Perek, Krystyna H. Chrzanowska, Małgorzata Krajewska-Walasek, Maria Łastowska
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Cancer
Subjects:
Medulloblastoma
DNA repair genes
Toxicity
Online Access:http://link.springer.com/article/10.1186/s12885-017-3211-y

Internet

http://link.springer.com/article/10.1186/s12885-017-3211-y

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