Heat shock protein 90 (Hsp90) as a molecular target for the development of novel drugs against the dermatophyte Trichophyton rubrum

Heat shock protein 90 (Hsp90) as a molecular target for the development of novel drugs against the dermatophyte Trichophyton rubrum

Treatment of fungal infections is difficult due to several reasons, such as side effects of drugs, emergence of resistant strains, and limited number of molecular targets for the drug compounds. In fungi, heat shock proteins (HSP) have been implicated in several processes with the conserved molecula...

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Bibliographic Details
Main Authors: Tiago R. Jacob, Nalu T. A. ePeres, Maíra P. Martins, Elza A. S. Lang, Pablo R. Sanches, Antonio eRossi, Nilce Maria eMartinez-Rossi
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Microbiology
Subjects:
Itraconazole
Dermatophytes
HSP
Drug Synergism
antifungal therapy
azole
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01241/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01241/full

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