Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload

Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload

Abstract Background The skeletal muscle plays a central role in glucose homeostasis through the uptake of glucose from the extracellular medium in response to insulin. A number of factors are known to disrupt the normal response to insulin leading to the emergence of insulin resistance (IR). Advance...

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Bibliographic Details
Main Authors: Marcel A. Vieira-Lara, Marleen B. Dommerholt, Wenxuan Zhang, Maaike Blankestijn, Justina C. Wolters, Fentaw Abegaz, Albert Gerding, Ydwine T. van der Veen, Rachel Thomas, Ronald P. van Os, Dirk-Jan Reijngoud, Johan W. Jonker, Janine K. Kruit, Barbara M. Bakker
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Biology
Subjects:
Insulin resistance
Skeletal muscle
Mitochondrial β-oxidation
Ageing
Online Access:https://doi.org/10.1186/s12915-021-01082-5

Internet

https://doi.org/10.1186/s12915-021-01082-5

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