New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition

New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition

A novel series of zileuton-hydroxycinnamic acid hybrids were synthesized and screened as 5-lipoxygenase (5-LO) inhibitors in stimulated HEK293 cells and polymorphonuclear leukocytes (PMNL). Zileuton’s (<b>1</b>) benzo[b]thiophene and hydroxyurea subunits combined with hydroxycinnamic aci...

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Bibliographic Details
Main Authors: Audrey Isabel Chiasson, Samuel Robichaud, Fanta J. Ndongou Moutombi, Mathieu P. A. Hébert, Maroua Mbarik, Marc E. Surette, Mohamed Touaibia
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
5-Lipoxygenase inhibitors
anti-leukotrienes
zileuton
sinapic acid
hydroxyurea
inflammation
Online Access:https://www.mdpi.com/1420-3049/25/20/4686

Internet

https://www.mdpi.com/1420-3049/25/20/4686

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