Influence of Urethra Sparing on Tumor Control Probability and Normal Tissue Complication Probability in Focal Dose Escalated Hypofractionated Radiotherapy: A Planning Study Based on Histopathology Reference

Influence of Urethra Sparing on Tumor Control Probability and Normal Tissue Complication Probability in Focal Dose Escalated Hypofractionated Radiotherapy: A Planning Study Based on Histopathology Reference

PurposeMultiparametric magnetic resonance tomography (mpMRI) and prostate specific membrane antigen positron emission tomography (PSMA-PET/CT) are used to guide focal radiotherapy (RT) dose escalation concepts. Besides improvements of treatment effectiveness, maintenance of a good quality of life is...

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Bibliographic Details
Main Authors: Simon K. B. Spohn, Ilias Sachpazidis, Rolf Wiehle, Benedikt Thomann, August Sigle, Peter Bronsert, Juri Ruf, Matthias Benndorf, Nils H. Nicolay, Tanja Sprave, Anca L. Grosu, Dimos Baltas, Constantinos Zamboglou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
hypofractionated radiotherapy
PSMA - prostate specific membrane antigen
focal dose escalation
tumor control probability (TCP)
NTCP (normal tissue complication probability) model
mpMRI
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.652678/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.652678/full

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