Support for the upregulation of serum thyrotropin by estrogens coming from the increased requirement of levothyroxine in one gynecomastic patient with excess of thyroxine-binding globulin secondary to exposure to exogenous estrogens
Thyroxine-binding globulin (TBG) is the liver-synthesized and estrogen-upregulated major plasma carrier of thyroid hormones with an affinity binding greater for T4 than T3. It is known that pregnancy, a physiologic state of estrogen-driven elevation of serum TBG, raises the requirement of L-T4 dose...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-12-01
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| Series: | Journal of Clinical and Translational Endocrinology Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214624518300388 |