Intestinal-specific TNFα overexpression induces Crohn's-like ileitis in mice.

Intestinal-specific TNFα overexpression induces Crohn's-like ileitis in mice.

Human and animal studies have clearly established tumor necrosis factor (TNF)α as an important mediator of Crohn's disease pathogenesis. However, whether systemic or only local TNFα overproduction is required for the development of chronic intestinal inflammation and Crohn's disease remain...

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Bibliographic Details
Main Authors: Giorgos Bamias, Mohamed I Dahman, Kristen O Arseneau, Mitchell Guanzon, Dennis Gruska, Theresa T Pizarro, Fabio Cominelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3748077?pdf=render

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http://europepmc.org/articles/PMC3748077?pdf=render

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