CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis

CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis

CD80 and CD86 are expressed on antigen presenting cells (APCs) and their role in providing costimulation to T cells is well established. However, it has been shown that these molecules can also be expressed by T cells, but the significance of this observation remains unknown. We have investigated st...

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Bibliographic Details
Main Authors: Blagoje Soskic, Louisa E. Jeffery, Alan Kennedy, David H. Gardner, Tie Zheng Hou, Neil Halliday, Cayman Williams, Daniel Janman, Behzad Rowshanravan, Gideon M. Hirschfield, David M. Sansom
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
CD80 and CD86
CD28 costimulation
CTLA-4
T cell activation
Treg
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.577655/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.577655/full

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