Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin.

The development of novel targeted therapies has become an important research focus for lung cancer treatment. Our previous study has shown leptomycin B (LMB) significantly inhibited proliferation of lung cancer cells; however, p53 wild type lung cancer cells were resistant to LMB. Therefore, the obj...

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Bibliographic Details
Main Authors: Chuanwen Lu, Changxia Shao, Everardo Cobos, Kamaleshwar P Singh, Weimin Gao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3296751?pdf=render