HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a broad range of human cancers. HIF inhibitors are under pre-clinical investigation and clinical trials, but there...

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Bibliographic Details
Main Authors: Shen-Han Lee, Monika Golinska, John R. Griffiths
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
Myc
Online Access:https://www.mdpi.com/2073-4409/10/9/2371