The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis

The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) patients exhibit diverse pathologies such as endoplasmic reticulum (ER) stress and mitochondrial dysfunction in motor neurons. Five to ten percent of patients have familial ALS, a form of the disease caused by mutations in ALS-related genes, while sporadic forms o...

Full description

Bibliographic Details
Main Authors: Kohji Fukunaga, Yasuharu Shinoda, Hideaki Tagashira
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Pharmacological Sciences
Subjects:
Amyotrophic lateral sclerosis
SIGMAR1
Mitochondrial injury
Energy production
TDP-43
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861314000334

Internet

http://www.sciencedirect.com/science/article/pii/S1347861314000334

Similar Items