New HSV-1 Anti-Viral 1′-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety

New HSV-1 Anti-Viral 1′-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety

New 1&#8242;-homocarbanucleoside analogs with an optically active substituted bicyclo[2.2.1]heptane skeleton as sugar moiety were synthesized. The pyrimidine analogs with uracil, 5-fluorouracil, thymine and cytosine and key intermediate with 6-chloropurine (<b>5</b>) as nucleobases w...

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Bibliographic Details
Main Authors: Constantin I. Tănase, Constantin Drăghici, Anamaria Hanganu, Lucia Pintilie, Maria Maganu, Alexandrina Volobueva, Ekaterina Sinegubova, Vladimir V. Zarubaev, Johan Neyts, Dirk Jochmans, Alexander V. Slita
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
1′-homocarbonucleosides
bicyclo[2.2.1]heptane nucleosides
6-chloropurine
6-substituted adenine nucleosides
antiviral activity
herpesviruses
molecular docking
Online Access:https://www.mdpi.com/1420-3049/24/13/2446

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https://www.mdpi.com/1420-3049/24/13/2446

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