Inverse Relationship between 15-Lipoxygenase-2 and PPAR-γ Gene Expression in Normal Epithelia Compared with Tumor Epithelia

Inverse Relationship between 15-Lipoxygenase-2 and PPAR-γ Gene Expression in Normal Epithelia Compared with Tumor Epithelia

15-Lipoxygenase-2 (15-LOX-2) synthesizes 15-S-hydroxyeicosatetraenoic acid (15-S-HETE), an endogenous ligand for the nuclear receptor, peroxisome proliferator-activated receptor-γ (PPAR-γ). Several studies have described an inverse relationship between 15-LOX-2 and PPAR-γ expression in normal versu...

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Bibliographic Details
Main Authors: Vemparala Subbarayan, Xiao-Chun Xu, Jeri Kim, Peiying Yang, Ashraful Hoque, Anita L. Sabichi, Norma Llansa, Gabriella Mendoza, Christopher J. Logothetis, Robert A. Newman, Scott M. Lippman, David G. Menter
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
15-lipoxygenase
prostate cancer
gene expression
peroxisome proliferator-activated receptor-γ
PPAR-γ
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800296

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http://www.sciencedirect.com/science/article/pii/S1476558605800296

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