A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs

A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs

Summary: Duchenne muscular dystrophy (DMD) is a muscle degenerating disease caused by dystrophin deficiency, for which therapeutic options are limited. To facilitate drug development, it is desirable to develop in vitro disease models that enable the evaluation of DMD declines in contractile perform...

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Bibliographic Details
Main Authors: Tomoya Uchimura, Toshifumi Asano, Takao Nakata, Akitsu Hotta, Hidetoshi Sakurai
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports Medicine
Subjects:
EFS training
muscle overuse
optogenetics
high-throughput
induced pluripotent stem cells
skeletal muscle cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121001312

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http://www.sciencedirect.com/science/article/pii/S2666379121001312

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