Intraventricular infusion of quinolinic acid impairs spatial learning and memory in young rats: a novel mechanism of lead-induced neurotoxicity

Intraventricular infusion of quinolinic acid impairs spatial learning and memory in young rats: a novel mechanism of lead-induced neurotoxicity

Abstract Background Lead (Pb), a heavy metal, and quinolinic acid (QA), a metabolite of the kynurenine pathway of tryptophan metabolism, are known neurotoxicants. Both Pb and QA impair spatial learning and memory. Pb activates astrocytes and microglia, which in turn induce the synthesis of QA. We hy...

Full description

Bibliographic Details
Main Authors: Abdur Rahman, Muddanna S. Rao, Khalid M. Khan
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Neuroinflammation
Subjects:
Quinolinic acid
Spatial learning
Memory
Lead
Neurotoxicity
Online Access:http://link.springer.com/article/10.1186/s12974-018-1306-2

Internet

http://link.springer.com/article/10.1186/s12974-018-1306-2

Similar Items